The Guide to the Eight Professional Competencies for Higher Education Substance Misuse Prevention (Professional Competencies Guide) was developed to provide a broad understanding of the range of skills necessary for orchestrating comprehensive campus prevention efforts. With the active engagement of seasoned personnel with extensive experience surrounding campus substance misuse prevention efforts, the resulting compilation organizes competencies within eight core areas; further, it provides specific resources helpful for each of these areas and for overall professional development. As a whole, this Professional Competencies Guide provides a current framework that helps campus leaders and dedicated professionals move things forward, to work more efficiently, and to be more effective.